Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.40 |
| ▸ | TUBB | P07437 | 2/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1244015 | 0.84 | KDM4E (0.38) | KDM4EALDH1A1GAAMAPTRAB9A | |
| SCHEMBL12388700 | 0.79 | KDM4E (0.41) | KDM4EALDH1A1GAANPC1MAPT | |
| SCHEMBL13395478 | 0.78 | KDM4E (0.44) | KDM4EALDH1A1GAANPC1MAPT | |
| SCHEMBL1242676 | 0.77 | DAO (0.42) | KDM4EALDH1A1HPGD | |
| SCHEMBL30990197 | 0.75 | ALOX15 (0.44) | KDM4EALDH1A1GAANPC1MAPT | |
| SCHEMBL2724382 | 0.74 | KDM4E (0.63) | KDM4EALDH1A1GAAMAPTRAB9A | |
| SCHEMBL30797259 | 0.74 | KDM4E (0.63) | KDM4EALDH1A1GAAMAPTRAB9A | |
| SCHEMBL13395589 | 0.72 | KDM4E (0.41) | KDM4EALDH1A1GAANPC1MAPT | |
| SCHEMBL830378 | 0.71 | ALDH1A1 (0.71) | KDM4EALDH1A1GAANPC1MAPT | |
| SCHEMBL2351650 | 0.71 | GABRA1 (0.60) | KDM4EALDH1A1GAANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029741-A1 | FUSED HETEROCYCLES | SEPRACOR INC. (US) | 2010-02-04 | — | — | US | disclosed |
| US-7579370-B2 | Fused heterocycles | SEPRACOR INC. (US) | 2009-08-25 | — | — | US | disclosed |
| WO-2009020814-A2 | FUSED HETEROCYCLES | SEPRACOR INC. (US) | 2009-02-12 | — | — | WO | disclosed |
| US-20080004328-A1 | FUSED HETEROCYCLES | SEPRACOR INC. (US) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029741-A1 | FUSED HETEROCYCLES | CHRNA4, CHRNB4, CHRNA3 | KDM4E 3881/4885ALDH1A1 2027/4885GAA 3012/4885 |
| US-20080004328-A1 | FUSED HETEROCYCLES | HRH3, HRH4, AHR | KDM4E 3354/4885ALDH1A1 2543/4885GAA 4425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.