SCHEMBL8254657

SCHEMBL8254657

NC1(c2ccc(F)cc2)CCC1

nearest known ligand 0.87

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 1/20 0.48
MAOB P27338 2/20 0.45
MAOA P21397 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2310506 0.98 SLC6A3 (0.47) SLC6A3MAOBMAOA
SCHEMBL2780627 0.95 SLC6A3 (0.53) SLC6A3
SCHEMBL8247834 0.93 SLC6A3 (0.57) SLC6A3
SCHEMBL7093776 0.93 SLC6A3 (0.57) SLC6A3
Hydrochloric Acid SCHEMBL18662811 0.93 SLC6A3 (0.52) SLC6A3
SCHEMBL56590 0.90 MAOB (0.48) SLC6A3MAOBMAOA
Hydrochloric Acid SCHEMBL1918396 0.88 MAOB (0.46) SLC6A3MAOBMAOA
SCHEMBL16007090 0.84 MAOB (0.43) SLC6A3MAOBMAOA
SCHEMBL12209696 0.80 MAOB (0.41) SLC6A3MAOBMAOA
SCHEMBL1240436 0.80 MAOB (0.41) SLC6A3MAOBMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103002897-B Certain amino-pyridazines, compositions thereof, and methods of use thereof 赛特凯恩蒂克公司 2017-06-09 CN claimed
CN-115260016-B Synthesis method of phenylcycloalkyl derivative 苏州爱玛特生物科技有限公司 2023-11-24 CN disclosed
US-11746091-B2 Cannabinoid receptor modulators ARENA PHARMACEUTICALS, INC. (US) 2023-09-05 US disclosed
US-20230033510-A1 Compounds and Methods for Treatment of Visceral Pain ARENA PHARMACEUTICALS, INC. 2023-02-02 US disclosed
EP-3362445-B1 OXADIAZOLE AMINE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME CHONG KUN DANG PHARMACEUTICAL CORP (KR) 2023-01-25 EP disclosed
CN-115260016-A Synthetic method of phenyl cycloalkyl derivative 苏州爱玛特生物科技有限公司 2022-11-01 CN disclosed
US-11214548-B2 Cannabinoid receptor modulators ARENA PHARMACEUTICALS, INC. (US) 2022-01-04 US disclosed
US-20210188781-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. 2021-06-24 US disclosed
US-20200078358-A1 Compounds and Methods for Treatment of Visceral Pain ARENA PHARMACEUTICALS, INC. 2020-03-12 US disclosed
US-20180354907-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. 2018-12-13 US disclosed
US-20090325932-A1 4-PIPERIDYLBENZAMIDES AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS HIGH POINT PHARMACEUTICALS, LLC 2009-12-31 US disclosed
US-7553861-B2 Dipeptidyl peptidase-IV inhibitors ALANTOS PHARMACEUTICALS HOLDING, INC. (US) 2009-06-30 US disclosed
US-7553861-B2 Dipeptidyl peptidase-IV inhibitors ALANTOS PHARMACEUTICALS HOLDING, INC. (US) 2009-06-30 US disclosed
US-20090118283-A1 Amide Derivatives as Kinase Inhibitors DEVGEN NV (BE) 2009-05-07 US disclosed
US-20090118283-A1 Amide Derivatives as Kinase Inhibitors DEVGEN NV (BE) 2009-05-07 US disclosed
WO-2008006703-A1 4-PIPERIDYLBENZAMIDES AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS HIGH POINT PHARMACEUTICALS, LLC (US) 2008-01-17 WO disclosed
EP-1878721-A1 4-Piperidylbenzamides as 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors NOVO NORDISK A/S (DK) 2008-01-16 EP disclosed
WO-2006116157-A9 DIPEPTIDYL PEPTIDASE-IV INHIBITORS ALANTOS PHARMACEUTICALS INC (US) 2007-03-01 WO disclosed
WO-2007006546-A1 AMIDE DERIVATIVES AS KINASE INHIBITORS DEVGEN N.V. (BE) 2007-01-18 WO disclosed
WO-2006116157-A2 DIPEPTIDYL PEPTIDASE-IV INHIBITORS ALANTOS PHARMACEUTICALS HOLDING, INC. (US) 2006-11-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200078358-A1 Compounds and Methods for Treatment of Visceral Pain VIP, FABP2, FABP6 SLC6A3 2891/4885MAOB 263/4885MAOA 404/4885
US-20180354907-A1 CANNABINOID RECEPTOR MODULATORS CNR1, CNR2, TRPV1 SLC6A3 3967/4885MAOB 2599/4885MAOA 2983/4885
US-20090118283-A1 Amide Derivatives as Kinase Inhibitors MAP3K1, CDK1, CDK2 SLC6A3 2118/4885MAOB 3033/4885MAOA 3019/4885
US-20090325932-A1 4-PIPERIDYLBENZAMIDES AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS HSD11B1, HSD3B1, HSD17B1 SLC6A3 4440/4885MAOB 1217/4885MAOA 1923/4885
US-11746091-B2 Cannabinoid receptor modulators CNR1, CNR2, TRPV1 SLC6A3 3967/4885MAOB 2599/4885MAOA 2983/4885
US-11214548-B2 Cannabinoid receptor modulators CNR1, CNR2, TRPV1 SLC6A3 3967/4885MAOB 2599/4885MAOA 2983/4885
US-20230033510-A1 Compounds and Methods for Treatment of Visceral Pain VIP, FABP2, FABP6 SLC6A3 2891/4885MAOB 263/4885MAOA 404/4885
US-20210188781-A1 CANNABINOID RECEPTOR MODULATORS CNR1, CNR2, TRPV1 SLC6A3 3967/4885MAOB 2599/4885MAOA 2983/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.