Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | IL2 | P60568 | 8/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8259732 | 0.89 | LMNA (0.37) | LMNAPOLBIL2ALDH1A1USP2 | |
| SCHEMBL8260246 | 0.87 | LMNA (0.39) | LMNAPOLBIL2ALDH1A1USP2 | |
| SCHEMBL8260160 | 0.84 | LMNA (0.38) | LMNAPOLBIL2ALDH1A1USP2 | |
| SCHEMBL8252236 | 0.82 | ALDH1A1 (0.39) | LMNAPOLBIL2ALDH1A1USP2 | |
| SCHEMBL8261523 | 0.82 | IL2 (0.42) | LMNAPOLBIL2ALDH1A1USP2 | |
| SCHEMBL8260033 | 0.81 | LMNA (0.36) | LMNAPOLBIL2ALDH1A1USP2 | |
| SCHEMBL8256822 | 0.80 | IL2 (0.46) | IL2ALDH1A1 | |
| SCHEMBL8258139 | 0.80 | IL2 (0.54) | IL2 | |
| SCHEMBL8260163 | 0.78 | IL2 (0.56) | IL2 | |
| SCHEMBL8259763 | 0.76 | POLB (0.41) | LMNAPOLBIL2ALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006081391-A2 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |