Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5316188 | 0.91 | HTR1A (0.44) | ALDH1A1MAPTKMT2AHTR1ATP53 | |
| SCHEMBL8258042 | 0.80 | HTR3E (0.48) | MAPTKDM4EHTR1AHTR7DRD2 | |
| SCHEMBL5268778 | 0.80 | MEN1 (0.48) | KMT2AHTR1AMEN1HTTHTR7 | |
| SCHEMBL4332120 | 0.77 | HTR1A (0.44) | ALDH1A1MAPTKDM4EKMT2AHTR1A | |
| SCHEMBL5270524 | 0.74 | MEN1 (0.54) | ALDH1A1MAPTKMT2AHTR1ATP53 | |
| SCHEMBL5270523 | 0.73 | ADRA1B (0.54) | ALDH1A1MAPTKMT2AHTR1ATP53 | |
| SCHEMBL5266680 | 0.72 | SLC6A2 (0.47) | HTR1AHTR7DRD2DRD4 | |
| SCHEMBL4318159 | 0.71 | ALDH1A1 (0.48) | ALDH1A1MAPTKDM4EKMT2AHTR1A | |
| SCHEMBL8255009 | 0.70 | ALDH1A1 (0.47) | ALDH1A1MAPTKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL4324247 | 0.69 | SMN1; SMN2 (0.47) | ALDH1A1MAPTHTR1ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006071730-A1 | PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | ASTRAZENECA AB (SE) | 2006-07-06 | — | — | WO | disclosed |