Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL230634 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRHCAR2KEAP1NFE2L2 | |
| SCHEMBL14152614 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRHCAR2KEAP1NFE2L2 | |
| Acetic Acid SCHEMBL29018083 | 0.94 | ALDH1A1 (0.59) | ALDH1A1TSHRHCAR2KEAP1NFE2L2 | |
| SCHEMBL9474617 | 0.89 | HCAR2 (0.56) | ALDH1A1TSHRHCAR2KEAP1NFE2L2 | |
| SCHEMBL8760880 | 0.89 | HCAR2 (0.56) | ALDH1A1TSHRHCAR2KEAP1NFE2L2 | |
| SCHEMBL8760886 | 0.89 | HCAR2 (0.56) | ALDH1A1TSHRHCAR2KEAP1NFE2L2 | |
| SCHEMBL11044892 | 0.87 | HCAR2 (0.54) | ALDH1A1TSHRHCAR2KEAP1NFE2L2 | |
| SCHEMBL1695596 | 0.85 | — | — | |
| SCHEMBL779039 | 0.85 | — | — | |
| SCHEMBL28977028 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210002332-A1 | SYSTEMS AND METHODS FOR FORMING BIOLOGICAL NANOWIRES AND APPLICATIONS THEREOF | YALE UNIVERSITY (US) | 2021-01-07 | — | — | US | disclosed |
| CN-108368075-A | Modified cytotoxins and therapeutic uses thereof | 加利福尼亚大学董事会 | 2018-08-03 | — | — | CN | disclosed |
| US-8859563-B2 | Bicyclic pyrimidinones and uses thereof | AVEXA LIMITED (AU) | 2014-10-14 | — | — | US | disclosed |
| US-20120232035-A1 | Bicyclic pyrimidinones and uses thereof | AVEXA LIMITED (AU) | 2012-09-13 | — | — | US | disclosed |
| US-8207334-B2 | Bicyclic pyrimidinones and uses thereof | AVEXA LIMITED (AU) | 2012-06-26 | — | — | US | disclosed |
| US-8143268-B2 | Bicyclic pyrimidinones and uses thereof | AVEXA LIMITED (AU) | 2012-03-27 | — | — | US | disclosed |
| EP-2114903-B1 | BICYCLIC PYRIMIDINONES AND USES THEREOF | AVEXA LTD (AU) | 2011-01-26 | — | — | EP | disclosed |
| US-20110009366-A1 | BICYCLIC PYRIMIDINONES AND USES THEREOF | AVEXA LIMITED (AU) | 2011-01-13 | — | — | US | disclosed |
| EP-2269992-A1 | Bicyclic pyrimidinones for the treatment of viral infections | Avexa Limited (AU) | 2011-01-05 | — | — | EP | disclosed |
| US-20100316712-A1 | PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF PARKINSON'S DISEASE AND RELATED DISORDERS | COMBINATORX, INCORPORATED (US) | 2010-12-16 | — | — | US | disclosed |
| US-20100316712-A1 | PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF PARKINSON'S DISEASE AND RELATED DISORDERS | COMBINATORX, INCORPORATED (US) | 2010-12-16 | — | — | US | disclosed |
| US-20100168063-A1 | BICYCLIC PYRIMIDINONES AND USES THEREOF | AVEXA LIMITED (AU) | 2010-07-01 | — | — | US | disclosed |
| EP-2114903-A1 | BICYCLIC PYRIMIDINONES AND USES THEREOF | Avexa Limited (AU) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008077188-A1 | BICYCLIC PYRIMIDINONES AND USES THEREOF | AVEXA LIMITED (AU) | 2008-07-03 | — | — | WO | disclosed |
| WO-2008079404-A2 | PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF PARKINSON'S DISEASE AND RELATED DISORDERS | COMBINATORX, INCORPORATED (US) | 2008-07-03 | — | — | WO | disclosed |
| CN-1060775-C | Fused tropane-derivatives as neurotransmitter reuptake inhibitors | NEURORES AS (DK) | 2001-01-17 | — | — | CN | disclosed |
| CN-1201461-A | Fused tropane-derivatives as neurotransmitter reuptake inhibitors | NEURORESEARCH A S (DK) | 1998-12-09 | — | — | CN | disclosed |
| US-4390631-A | INCUBATION WITH A WATER SOLUBLE IRON COMPOUND | NITTO CHEMICAL INDUSTRY CO., LTD. (JP) | 1983-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168063-A1 | BICYCLIC PYRIMIDINONES AND USES THEREOF | TPMT, TYMP, DPYD | ALDH1A1 337/4885TSHR 4293/4885HCAR2 1823/4885 |
| US-20100316712-A1 | PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF PARKINSON'S DISEASE AND RELATED DISORDERS | PARK7, SNCA, COMT | ALDH1A1 397/4885TSHR 3446/4885HCAR2 2397/4885 |
| US-20120232035-A1 | Bicyclic pyrimidinones and uses thereof | TPMT, TYMP, DPYD | ALDH1A1 337/4885TSHR 4293/4885HCAR2 1823/4885 |
| US-20110009366-A1 | BICYCLIC PYRIMIDINONES AND USES THEREOF | TPMT, TYMP, DPYD | ALDH1A1 337/4885TSHR 4293/4885HCAR2 1823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.