Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 14/20 | 0.57 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8260024 | 0.91 | ALOX15 (0.59) | PYGL | |
| SCHEMBL22534020 | 0.85 | MAOB (0.60) | — | |
| SCHEMBL3609215 | 0.80 | SMYD3 (0.69) | PYGLHRH4HRH3SMYD3 | |
| SCHEMBL3603062 | 0.80 | SMYD3 (0.69) | PYGLHRH4HRH3SMYD3 | |
| SCHEMBL3603066 | 0.80 | SMYD3 (0.69) | PYGLHRH4HRH3SMYD3 | |
| SCHEMBL22373887 | 0.77 | ADAMTS4 (0.50) | SMYD3 | |
| SCHEMBL8251733 | 0.77 | ADAMTS4 (0.50) | SMYD3 | |
| SCHEMBL18767312 | 0.77 | MAOB (0.67) | — | |
| SCHEMBL30578672 | 0.77 | SMYD3 (0.76) | PYGLHRH4HRH3SMYD3 | |
| SCHEMBL8255991 | 0.76 | SMYD3 (0.58) | SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820699-B2 | Cyclic amines | HOFFMANN-LA ROCHE INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-7820699-B2 | Cyclic amines | HOFFMANN-LA ROCHE INC. (US) | 2010-10-26 | — | — | US | disclosed |
| WO-2006114401-A2 | NOVEL CYCLIC AMINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-11-02 | — | — | WO | disclosed |