Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 6/20 | 0.71 |
| ▸ | CTSB | P07858 | 3/20 | 0.71 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.66 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.63 |
| ▸ | CASP3 | P42574 | 2/20 | 0.62 |
| ▸ | CASP7 | P55210 | 1/20 | 0.61 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.61 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.60 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.60 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8259042 | 0.99 | CTSL (0.70) | CTSLCTSBPSMB5PSMB2CASP3 | |
| SCHEMBL30490629 | 0.94 | PSMB5 (0.73) | CTSLCTSBPSMB5PSMB2CASP3 | |
| SCHEMBL8261586 | 0.92 | CASP3 (0.68) | CTSLCTSBCASP3CASP7 | |
| SCHEMBL8260998 | 0.89 | CTSL (0.69) | CTSLCTSBPSMB5CASP3CASP7 | |
| SCHEMBL8259747 | 0.88 | CTSL (0.68) | CTSLCTSBCASP3CASP7 | |
| SCHEMBL19944919 | 0.88 | CASP3 (0.70) | CTSLCTSBPSMB5CASP3CASP7 | |
| SCHEMBL8260989 | 0.88 | CASP3 (0.67) | CTSLCTSBPSMB5CASP3CASP7 | |
| SCHEMBL11998316 | 0.87 | PSMB5 (0.68) | CTSLCTSBPSMB5CASP3CASP7 | |
| SCHEMBL7353898 | 0.86 | CTSL (0.76) | CTSLCTSBCASP3CASP7CAPN1 | |
| SCHEMBL7353893 | 0.86 | CTSL (0.76) | CTSLCTSBCASP3CASP7CAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589066-B2 | Such as N-carbobenzyloxy-phenylalanyl-phenylalanylal; for treating cancer, inflammation, and/or autoimmune diseases; suppresses endogenous antigenic peptide generation | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2009-09-15 | — | — | US | disclosed |
| US-7589066-B2 | Such as N-carbobenzyloxy-phenylalanyl-phenylalanylal; for treating cancer, inflammation, and/or autoimmune diseases; suppresses endogenous antigenic peptide generation | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2009-09-15 | — | — | US | disclosed |
| WO-2006099261-A2 | POTENT AND SPECIFIC IMMUNOPROTEASOME INHIBITORS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2006-09-21 | — | — | WO | disclosed |