Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 7/20 | 0.67 |
| ▸ | CASP7 | P55210 | 3/20 | 0.58 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.57 |
| ▸ | CASP1 | P29466 | 4/20 | 0.56 |
| ▸ | CASP9 | P55211 | 2/20 | 0.56 |
| ▸ | CASP4 | P49662 | 1/20 | 0.55 |
| ▸ | CTSL | P07711 | 4/20 | 0.54 |
| ▸ | CTSB | P07858 | 3/20 | 0.54 |
| ▸ | CTSS | P25774 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8261586 | 0.89 | CASP3 (0.68) | CASP3CASP7CASP1CASP9CTSL | |
| SCHEMBL8260299 | 0.88 | CTSL (0.71) | CASP3CASP7PSMB5CTSLCTSB | |
| SCHEMBL8259042 | 0.87 | CTSL (0.70) | CASP3CASP7PSMB5CASP1CASP9 | |
| SCHEMBL7357819 | 0.86 | PSMB5 (0.54) | CASP3PSMB5CTSLCTSBCTSS | |
| SCHEMBL7357823 | 0.86 | PSMB5 (0.54) | CASP3PSMB5CTSLCTSBCTSS | |
| SCHEMBL7357814 | 0.86 | PSMB5 (0.54) | CASP3PSMB5CTSLCTSBCTSS | |
| SCHEMBL7357817 | 0.86 | PSMB5 (0.54) | CASP3PSMB5CTSLCTSBCTSS | |
| SCHEMBL8259747 | 0.85 | CTSL (0.68) | CASP3CASP7CASP1CASP9CTSL | |
| SCHEMBL2250051 | 0.84 | CTSB (0.70) | PSMB5CTSLCTSBCTSS | |
| SCHEMBL8259761 | 0.84 | CTSB (0.70) | PSMB5CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589066-B2 | Such as N-carbobenzyloxy-phenylalanyl-phenylalanylal; for treating cancer, inflammation, and/or autoimmune diseases; suppresses endogenous antigenic peptide generation | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2009-09-15 | — | — | US | disclosed |
| US-7589066-B2 | Such as N-carbobenzyloxy-phenylalanyl-phenylalanylal; for treating cancer, inflammation, and/or autoimmune diseases; suppresses endogenous antigenic peptide generation | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2009-09-15 | — | — | US | disclosed |
| WO-2006099261-A2 | POTENT AND SPECIFIC IMMUNOPROTEASOME INHIBITORS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2006-09-21 | — | — | WO | disclosed |