Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.79 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.79 |
| ▸ | DRD2 | P14416 | 8/20 | 0.75 |
| ▸ | DRD1 | P21728 | 8/20 | 0.75 |
| ▸ | DRD5 | P21918 | 8/20 | 0.75 |
| ▸ | DRD3 | P35462 | 6/20 | 0.75 |
| ▸ | DRD4 | P21917 | 5/20 | 0.75 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | GMNN | O75496 | 1/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.75 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.75 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.75 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.75 |
| ▸ | MTOR | P42345 | 1/20 | 0.75 |
| ▸ | BLM | P54132 | 1/20 | 0.75 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11820101 | 0.91 | DRD2 (0.71) | KDM4ECHRNA7DRD2DRD1DRD5 | |
| SCHEMBL11819270 | 0.89 | DRD2 (0.69) | KDM4ECHRNA7DRD2DRD1DRD5 | |
| SCHEMBL30324538 | 0.88 | CHRNA7 (1.00) | KDM4ECHRNA7DRD2DRD1DRD5 | |
| SCHEMBL168248 | 0.88 | CHRNA7 (1.00) | KDM4ECHRNA7DRD2DRD1DRD5 | |
| SCHEMBL1055807 | 0.88 | KDM4E (1.00) | KDM4ECHRNA7DRD2DRD1DRD5 | |
| SCHEMBL29471003 | 0.86 | DRD5 (1.00) | KDM4ECHRNA7DRD2DRD1DRD5 | |
| SCHEMBL12610513 | 0.86 | DRD5 (1.00) | KDM4ECHRNA7DRD2DRD1DRD5 | |
| SCHEMBL30522313 | 0.86 | DRD5 (1.00) | KDM4ECHRNA7DRD2DRD1DRD5 | |
| SCHEMBL13203882 | 0.85 | KDM4E (0.62) | KDM4ECHRNA7DRD2DRD1DRD5 | |
| SCHEMBL25774111 | 0.83 | HTR1A (0.66) | KDM4ECHRNA7DRD2DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9481676-B2 | Azepino[4,5-B]indoles and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2016-11-01 | — | — | US | disclosed |
| US-9409910-B2 | Azepino[4,5-B]indoles and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2016-08-09 | — | — | US | disclosed |
| US-20140088087-A1 | AZEPINO[4,5-B]INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2014-03-27 | — | — | US | disclosed |
| US-20130190295-A1 | AZEPINO[4,5-B]INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2013-07-25 | — | — | US | disclosed |
| US-20100152163-A1 | AZEPINO[4,5-B]INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. | 2010-06-17 | — | — | US | disclosed |
| US-20100152163-A1 | AZEPINO[4,5-B]INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. | 2010-06-17 | — | — | US | disclosed |
| WO-2010051503-A1 | AZEPINO [4, 5-B] INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2010-05-06 | — | — | WO | disclosed |
| WO-2006088949-A1 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF HISTONE DEACETYLASE | MIIKANA THERAPEUTICS, INC. (US) | 2006-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190295-A1 | AZEPINO[4,5-B]INDOLES AND METHODS OF USE | HTR2C, HTR5A, HTR4 | KDM4E 710/4885CHRNA7 90/4885DRD2 124/4885 |
| US-20100152163-A1 | AZEPINO[4,5-B]INDOLES AND METHODS OF USE | HTR2C, HTR5A, HTR4 | KDM4E 710/4885CHRNA7 90/4885DRD2 124/4885 |
| US-20140088087-A1 | AZEPINO[4,5-B]INDOLES AND METHODS OF USE | HTR2C, HTR5A, HTR4 | KDM4E 710/4885CHRNA7 90/4885DRD2 124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.