Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4475302 | 0.86 | EPHX2 (0.53) | SLC6A3KCNH2FOLH1EPHX2 | |
| SCHEMBL13932368 | 0.83 | SLC6A3 (0.49) | FAAHCYP3A4CYP2D6TSHRALOX12 | |
| SCHEMBL4465490 | 0.82 | EPHX2 (0.49) | RAB9ASLC6A3SMN1; SMN2CACNA1BKCNH2 | |
| SCHEMBL4475311 | 0.82 | KCNH2 (0.45) | FAAHCYP3A4CYP2D6TSHRALOX12 | |
| SCHEMBL4462507 | 0.82 | SLC6A9 (0.52) | TBXA2RSLC6A3KCNH2FOLH1EPHX2 | |
| SCHEMBL4460835 | 0.81 | POLB (0.53) | SLC6A3KCNH2FOLH1EPHX2 | |
| SCHEMBL4459399 | 0.80 | KCNH2 (0.59) | SLC6A3KCNH2EPHX2 | |
| SCHEMBL4457002 | 0.79 | SLC6A9 (0.55) | CYP3A4CYP2D6MAPK1RAB9AMEN1 | |
| SCHEMBL8260134 | 0.79 | SLC6A3 (0.46) | FAAHCYP3A4CYP2D6TSHRALOX12 | |
| SCHEMBL8262130 | 0.79 | SLC6A3 (0.46) | FAAHCYP3A4CYP2D6TSHRALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511077-B2 | Diamine calcium channel blockers | NEUROMED PHARMACEUTICALS LTD. (CA) | 2009-03-31 | — | — | US | disclosed |
| WO-2006084369-A1 | DIAMINE CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2006-08-17 | — | — | WO | disclosed |