Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | VCP | P55072 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14023045 | 0.85 | ADRB3 (0.49) | VCPALDH1A1 | |
| SCHEMBL8262374 | 0.84 | ADRB2 (0.48) | MCL1VCPPARP1 | |
| SCHEMBL24302272 | 0.78 | ALDH1A1 (0.51) | GPR119ALDH1A1 | |
| SCHEMBL28943536 | 0.75 | PARP1 (0.52) | GPR119ALDH1A1PARP1 | |
| SCHEMBL23635039 | 0.74 | GPR119 (0.43) | GPR119ALDH1A1PDE3BPDE3A | |
| SCHEMBL4213070 | 0.73 | DRD4 (0.57) | GPR119ALDH1A1 | |
| SCHEMBL8267242 | 0.73 | KDM4E (0.50) | GPR119ALDH1A1 | |
| SCHEMBL8263806 | 0.71 | ADRB3 (0.65) | — | |
| SCHEMBL4899642 | 0.71 | ADRB3 (0.65) | — | |
| SCHEMBL4902486 | 0.71 | ADRB3 (0.65) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006060122-A9 | CARDIOTONIC COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST BETA-ADRENERGIC RECEPTORS AND PHOSPHODIESTERASE | ARTESIAN THERAPEUTICS INC (US) | 2006-08-17 | — | — | WO | disclosed |
| WO-2006060122-A2 | CARDIOTONIC COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST BETA-ADRENERGIC RECEPTORS AND PHOSPHODIESTERASE | ARTESIAN THERAPEUTICS, INC. (US) | 2006-06-08 | — | — | WO | disclosed |