Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 9/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.34 |
| ▸ | TACR3 | P29371 | 2/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | TACR2 | P21452 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3236142 | 0.88 | SLC6A9 (0.41) | TRPV4SLC6A9TACR3TACR1CYP2D6 | |
| SCHEMBL3240772 | 0.80 | SLC6A9 (0.45) | TRPV4SLC6A9 | |
| SCHEMBL3244977 | 0.78 | TACR1 (0.39) | TRPV4SLC6A9TACR3TACR1 | |
| SCHEMBL3238790 | 0.77 | LMNA (0.35) | SLC6A9CYP2D6 | |
| SCHEMBL5353056 | 0.76 | SLC6A9 (0.42) | SLC6A9CYP2D6CYP2C19SLC6A5 | |
| SCHEMBL3238426 | 0.76 | SLC6A9 (0.42) | SLC6A9CYP2C19SLC6A5 | |
| SCHEMBL3238049 | 0.76 | ITGA4 (0.49) | SLC6A9 | |
| SCHEMBL13303995 | 0.76 | MTTP (0.40) | TRPV4TACR3TACR1CCR2 | |
| SCHEMBL3832646 | 0.75 | SLC6A9 (0.52) | SLC6A9TACR1CYP2D6CYP2C19SLC6A5 | |
| SCHEMBL3008740 | 0.75 | SLC6A9 (0.52) | SLC6A9TACR1CYP2D6CYP2C19SLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006067423-A1 | GLYCINE TRANSPORT INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-06-29 | — | — | WO | disclosed |