Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 14/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3237806 | 0.89 | ROCK2 (0.43) | SLC6A9ROCK2 | |
| SCHEMBL12132690 | 0.87 | SLC6A9 (0.40) | SLC6A9CYP2D6CYP2C19SLC6A5 | |
| SCHEMBL5363493 | 0.84 | ROCK2 (0.38) | SLC6A9CYP2D6CYP2C19SLC6A5ROCK2 | |
| SCHEMBL3239591 | 0.81 | KMT2A (0.47) | SLC6A9CYP2D6 | |
| SCHEMBL3238200 | 0.80 | CCR5 (0.39) | SLC6A9CYP2C19SLC6A5 | |
| SCHEMBL26840793 | 0.80 | RXFP1 (0.38) | SLC6A9 | |
| SCHEMBL3236158 | 0.79 | SLC6A9 (0.41) | SLC6A9 | |
| SCHEMBL1350280 | 0.79 | SLC6A9 (0.45) | SLC6A9CYP2D6CYP2C19SLC6A5ROCK2 | |
| SCHEMBL3236142 | 0.79 | SLC6A9 (0.41) | SLC6A9CYP2D6CYP2C19SLC6A5 | |
| SCHEMBL3008740 | 0.79 | SLC6A9 (0.52) | SLC6A9CYP2D6CYP2C19SLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007147834-A1 | GLYCINE TRANSPORTER INHIBITING COMPOUNDS AND USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2007-12-27 | — | — | WO | claimed |
| WO-2007147834-A1 | GLYCINE TRANSPORTER INHIBITING COMPOUNDS AND USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2007-12-27 | — | — | WO | disclosed |
| WO-2007147834-A1 | GLYCINE TRANSPORTER INHIBITING COMPOUNDS AND USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2007-12-27 | — | — | WO | disclosed |