Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 3/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5507986 | 0.74 | THRB (0.59) | SMN1; SMN2HSD17B10TP53THRBRXFP1 | |
| SCHEMBL5507402 | 0.73 | HSD17B10 (0.50) | SMN1; SMN2HSD17B10TP53THRBRXFP1 | |
| SCHEMBL16220611 | 0.65 | NAMPT (0.50) | SMN1; SMN2HSD17B10THRBRXFP1MAPT | |
| SCHEMBL19538866 | 0.63 | MAPT (0.59) | SMN1; SMN2HSD17B10TP53MAPTALDH1A1 | |
| SCHEMBL8577441 | 0.62 | MEN1 (0.68) | SMN1; SMN2HSD17B10MAPTALDH1A1KDM4E | |
| SCHEMBL27400764 | 0.61 | MCL1 (0.57) | SMN1; SMN2HSD17B10TP53THRBRXFP1 | |
| SCHEMBL7832820 | 0.61 | SMN1; SMN2 (0.53) | SMN1; SMN2HSD17B10TP53PSMB8MAPT | |
| SCHEMBL27684724 | 0.61 | THRB (0.50) | SMN1; SMN2HSD17B10TP53THRBRXFP1 | |
| SCHEMBL12868309 | 0.60 | THRB (0.44) | SMN1; SMN2HSD17B10THRBRXFP1MAPT | |
| SCHEMBL6182307 | 0.60 | MCL1 (0.56) | SMN1; SMN2HSD17B10THRBRXFP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006037996-A1 | NOVEL CYCLIC AND ACYCLIC PROPENONES FOR TREATING CNS DISORDERS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2006-04-13 | — | — | WO | disclosed |