Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL593096 | 0.93 | MLNR (0.36) | MLNRFAAHHTR1ADRD2ADRA1D | |
| SCHEMBL593208 | 0.92 | CCR5 (0.39) | HTR1ADRD2ADRA1DHTR1BADRA1A | |
| SCHEMBL593105 | 0.91 | FAAH (0.35) | MLNRFAAHHTR1ADRD2ADRA1D | |
| SCHEMBL593094 | 0.91 | CXCR3 (0.38) | FAAHDRD2 | |
| SCHEMBL594223 | 0.91 | HTR1A (0.37) | MLNRFAAHHTR1ADRD2ADRA1D | |
| SCHEMBL593551 | 0.91 | CCR5 (0.41) | — | |
| SCHEMBL593104 | 0.90 | FAAH (0.33) | MLNRFAAHHTR1ADRD2ADRA1D | |
| SCHEMBL594222 | 0.89 | MLNR (0.35) | MLNRFAAHHTR1ADRD2ADRA1D | |
| SCHEMBL594391 | 0.88 | OPRL1 (0.39) | FAAH | |
| SCHEMBL593097 | 0.88 | MAP3K11 (0.38) | MLNRFAAHSSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006044497-A2 | SPIROPIPERIDINE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHERMER’S DISEASE | MERCK & CO., INC. (US) | 2006-04-27 | — | — | WO | disclosed |