SCHEMBL826836

SCHEMBL826836

CCc1ccc(CCOc2ccc(CC3SC(=O)N(C)C3=O)cc2)nc1

nearest known ligand 0.70

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PPARG P37231 12/20 0.70
CYP3A4 P08684 1/20 0.69
RXRA P19793 1/20 0.69
MPC2 O95563 1/20 0.47
CYP2C8 P10632 1/20 0.47
CYP2C9 P11712 1/20 0.47
KDM4A O75164 1/20 0.42
USP2 O75604 1/20 0.42
POLB P06746 1/20 0.42
ALOX15 P16050 1/20 0.42
KDM4C Q9H3R0 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
HRH3 Q9Y5N1 4/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
FFAR1 O14842 1/20 0.38
AURKA O14965 1/20 0.38
HPGD P15428 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4181113 0.90 PPARG (0.65) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL18323953 0.88 PPARG (0.66) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL1054873 0.88 PPARG (0.66) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL20697606 0.87 PPARG (0.67) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL11925103 0.87 PPARG (0.64) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL12074888 0.87 PPARG (0.67) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL12045501 0.86 PPARG (0.66) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL19849386 0.85 PPARG (0.60) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL23680506 0.85 PPARG (0.74) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL12045525 0.85 PPARG (0.64) PPARGCYP3A4RXRAMPC2CYP2C8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11767317-B1 Methods of synthesizing enantiopure deuterium-enriched pioglitazone POXEL SA (FR) 2023-09-26 US disclosed
US-20220211682-A1 5-DEUTERO-2,4-THIAZOLIDINEDIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME DEUTERX, LLC 2022-07-07 US disclosed
EP-2445343-B1 PRODRUGS OF NH-ACIDIC COMPOUNDS ALKERMES PHARMA IRELAND LTD (IE) 2021-08-04 EP disclosed
US-10723728-B2 Prodrugs of Nh-acidic compounds ALKERMES PHARMA IRELAND LIMITED (IE) 2020-07-28 US disclosed
US-10428058-B2 Prodrugs of NH-acidic compounds ALKERMES PHARMA IRELAND LIMITED (IE) 2019-10-01 US disclosed
US-20190284181-A9 PRODRUGS OF NH-ACIDIC COMPOUNDS JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2019-09-19 US disclosed
US-20190031648-A1 PRODRUGS OF NH-ACIDIC COMPOUNDS ALKERMES PHARMA IRELAND LTD (IE) 2019-01-31 US disclosed
US-10040787-B2 Prodrugs of NH-acidic compounds ALKERMES PHARMA IRELAND LIMITED (IE) 2018-08-07 US disclosed
US-20180194732-A1 MULTI-API LOADING PRODRUGS JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2018-07-12 US disclosed
EP-2655314-B1 MULTI-API LOADING PRODRUGS ALKERMES PHARMA IRELAND LTD (IE) 2018-02-07 EP disclosed
US-20150376143-A1 Prodrugs of NH-Acidic Compounds ALKERMES PHARMA IRELAND LTD (IE) 2015-12-31 US disclosed
US-9102618-B2 Prodrugs of NH-acidic compounds ALKERMES PHARMA IRELAND LIMITED (IE) 2015-08-11 US disclosed
US-20140221653-A1 Prodrugs of NH-Acidic Compounds ALKERMES PHARMA IRELAND LIMITED (IE) 2014-08-07 US disclosed
US-20120202823-A1 Multi-API Loading Prodrugs ALKERMES, INC. 2012-08-09 US disclosed
EP-2445343-A1 PRODRUGS OF NH-ACIDIC COMPOUNDS Alkermes, Inc. (US) 2012-05-02 EP disclosed
WO-2011163594-A2 PRODRUGS OF NH-ACIDIC COMPOUNDS: ESTER, CARBONATE, CARBAMATE AND PHOSPHONATE DERIVATIVES ALKERMES, INC. (US) 2011-12-29 WO disclosed
US-20110319422-A1 PRODRUGS OF NH-ACIDIC COMPOUNDS: ESTER, CARBONATE, CARBAMATE AND PHOSPHONATE DERIVATIVES ALKERMES, INC. (US) 2011-12-29 US disclosed
US-20110319422-A1 PRODRUGS OF NH-ACIDIC COMPOUNDS: ESTER, CARBONATE, CARBAMATE AND PHOSPHONATE DERIVATIVES ALKERMES, INC. (US) 2011-12-29 US disclosed
US-20110003828-A1 PRODRUGS OF NH-ACIDIC COMPOUNDS ALKERMES, INC. 2011-01-06 US disclosed
WO-2010151711-A1 PRODRUGS OF NH-ACIDIC COMPOUNDS ALKERMES, INC. (US) 2010-12-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11767317-B1 Methods of synthesizing enantiopure deuterium-enriched pioglitazone PPARD, GLP1R, DPP4 PPARG 7/4885CYP3A4 13/4885RXRA 29/4885
US-20150376143-A1 Prodrugs of NH-Acidic Compounds SI, NAAA, NIT2 PPARG 3557/4885CYP3A4 733/4885RXRA 4625/4885
US-20190031648-A1 PRODRUGS OF NH-ACIDIC COMPOUNDS SI, NAAA, NIT2 PPARG 3557/4885CYP3A4 733/4885RXRA 4625/4885
US-10040787-B2 Prodrugs of NH-acidic compounds SI, NAAA, NIT2 PPARG 3557/4885CYP3A4 733/4885RXRA 4625/4885
US-20190284181-A9 PRODRUGS OF NH-ACIDIC COMPOUNDS SI, NAAA, NIT2 PPARG 3557/4885CYP3A4 733/4885RXRA 4625/4885
US-10428058-B2 Prodrugs of NH-acidic compounds SI, NAAA, NIT2 PPARG 3557/4885CYP3A4 733/4885RXRA 4625/4885
US-20220211682-A1 5-DEUTERO-2,4-THIAZOLIDINEDIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME SLC5A2, PPARD, DPP4 PPARG 10/4885CYP3A4 108/4885RXRA 213/4885
US-20140221653-A1 Prodrugs of NH-Acidic Compounds SI, NAAA, NIT2 PPARG 3557/4885CYP3A4 733/4885RXRA 4625/4885
US-20110003828-A1 PRODRUGS OF NH-ACIDIC COMPOUNDS SI, NAAA, NIT2 PPARG 3557/4885CYP3A4 733/4885RXRA 4625/4885
US-10723728-B2 Prodrugs of Nh-acidic compounds SI, NAAA, NIT2 PPARG 3557/4885CYP3A4 733/4885RXRA 4625/4885
US-20120202823-A1 Multi-API Loading Prodrugs AADAC, PAICS, ABCG2 PPARG 2143/4885CYP3A4 69/4885RXRA 3793/4885
US-20110319422-A1 PRODRUGS OF NH-ACIDIC COMPOUNDS: ESTER, CARBONATE, CARBAMATE AND PHOSPHONATE DERIVATIVES PHPT1, SI, CA6 PPARG 3793/4885CYP3A4 765/4885RXRA 4782/4885
US-20180194732-A1 MULTI-API LOADING PRODRUGS AADAC, PAICS, ABCG2 PPARG 2143/4885CYP3A4 69/4885RXRA 3793/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.