Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 9/20 | 0.70 |
| ▸ | MMP2 | P08253 | 6/20 | 0.70 |
| ▸ | MMP1 | P03956 | 6/20 | 0.70 |
| ▸ | MMP7 | P09237 | 4/20 | 0.70 |
| ▸ | MMP9 | P14780 | 4/20 | 0.70 |
| ▸ | MMP8 | P22894 | 4/20 | 0.70 |
| ▸ | MMP13 | P45452 | 4/20 | 0.70 |
| ▸ | MMP12 | P39900 | 3/20 | 0.70 |
| ▸ | MYC | P01106 | 1/20 | 0.52 |
| ▸ | WDR5 | P61964 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14269135 | 0.88 | MMP3 (0.57) | MMP3MMP2MMP1MMP7MMP9 | |
| SCHEMBL13226432 | 0.88 | MMP3 (0.57) | MMP3MMP2MMP1MMP7MMP9 | |
| SCHEMBL2984201 | 0.88 | MMP3 (0.72) | MMP3MMP2MMP1MMP7MMP9 | |
| SCHEMBL8268658 | 0.82 | MMP3 (1.00) | MMP3MMP2MMP1MMP7MMP9 | |
| SCHEMBL13208686 | 0.82 | MMP3 (1.00) | MMP3MMP2MMP1MMP7MMP9 | |
| SCHEMBL16802797 | 0.81 | MMP3 (0.80) | MMP3MMP2MMP1MMP7MMP9 | |
| SCHEMBL16802791 | 0.81 | MMP3 (0.80) | MMP3MMP2MMP1MMP7MMP9 | |
| SCHEMBL14640654 | 0.80 | ALDH1A1 (0.46) | MMP3MMP2MMP1MMP7MMP9 | |
| SCHEMBL13208646 | 0.78 | MMP3 (0.59) | MMP3MMP2MMP1MMP7MMP9 | |
| SCHEMBL14260034 | 0.78 | MMP3 (0.59) | MMP3MMP2MMP1MMP7MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318945-B2 | Metalloprotein inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-11-27 | — | — | US | disclosed |
| US-20120041032-A1 | METALLOPROTEIN INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO (US) | 2012-02-16 | — | — | US | disclosed |
| US-8008510-B2 | Metalloprotein inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-08-30 | — | — | US | disclosed |
| US-20100173952-A1 | METALLOPROTEIN INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA OFFICE OF TECHNOLOGY TRANSFER (US) | 2010-07-08 | — | — | US | disclosed |
| US-7705164-B2 | Metalloprotein inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-04-27 | — | — | US | disclosed |
| US-20080161362-A1 | Metalloprotein Inhibitors | REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO UCSD TECHNOLOGY TRANSFER OFFICE (US) | 2008-07-03 | — | — | US | disclosed |
| WO-2006028523-A2 | HYDROXYPYRIDINONE, HYDROXYPYRIDINETHIONE, PYRONE, AND THIOPYRONE METALLOPROTEIN INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO USDC Technology Transfer Office (US) | 2006-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161362-A1 | Metalloprotein Inhibitors | SOD1, ZFX, SOD3 | MMP3 50/4885MMP2 21/4885MMP1 9/4885 |
| US-20100173952-A1 | METALLOPROTEIN INHIBITORS | SOD1, ZFX, SOD3 | MMP3 50/4885MMP2 21/4885MMP1 9/4885 |
| US-20120041032-A1 | METALLOPROTEIN INHIBITORS | SOD1, ZFX, SOD3 | MMP3 50/4885MMP2 21/4885MMP1 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.