Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NT5E | P21589 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3612595 | 0.87 | CYP11B2 (0.44) | MAPK9MAPK10MAPK8MAPK14NT5E | |
| SCHEMBL3615539 | 0.86 | PTGS2 (0.44) | LMNATSHRMAPK14PTGS2 | |
| SCHEMBL3604665 | 0.85 | RARG (0.42) | NR3C2 | |
| SCHEMBL3608038 | 0.85 | PTGS2 (0.41) | NT5EPTGS2 | |
| SCHEMBL8268988 | 0.80 | KHK (0.41) | MAPK9MAPK10MAPK8NR3C2SMN1; SMN2 | |
| SCHEMBL4558438 | 0.75 | CA9 (0.43) | PTGS2 | |
| SCHEMBL3594691 | 0.71 | PTGS2 (0.39) | NT5EPTGS2 | |
| SCHEMBL8269687 | 0.70 | SIGMAR1 (0.32) | MAPK14PTGS2 | |
| SCHEMBL3607275 | 0.70 | PTGS2 (0.44) | NT5EPTGS2 | |
| SCHEMBL8268975 | 0.70 | KHK (0.41) | PIK3CDKHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006044528-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |