Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.32 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.32 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13513892 | 0.91 | CHRM4 (0.36) | SIGMAR1TMEM97CHRM4ALDH1A1KMT2A | |
| SCHEMBL8268948 | 0.87 | OPRK1 (0.33) | SIGMAR1KCNH2ALDH1A1KMT2ATEAD1 | |
| SCHEMBL8268962 | 0.85 | MEN1 (0.40) | SIGMAR1CHRM4KCNH2ALDH1A1KMT2A | |
| SCHEMBL8268207 | 0.85 | ACHE (0.37) | CHRM4KMT2ATEAD1LMNA | |
| SCHEMBL8269820 | 0.83 | FFAR4 (0.38) | SIGMAR1CHRM4KMT2A | |
| SCHEMBL13611497 | 0.81 | TEAD1 (0.43) | SIGMAR1CHRM4KCNH2ALDH1A1TEAD1 | |
| SCHEMBL8268946 | 0.81 | PSEN1 (0.40) | TEAD1POLB | |
| SCHEMBL13611493 | 0.81 | NR1H2 (0.41) | — | |
| SCHEMBL13611862 | 0.80 | MCHR1 (0.37) | SIGMAR1 | |
| SCHEMBL8269821 | 0.79 | TEAD1 (0.37) | ALDH1A1KMT2ATEAD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006043064-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2006-04-27 | — | — | WO | disclosed |