Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 5/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | CCR2 | P41597 | 2/20 | 0.30 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13611599 | 0.91 | OPRK1 (0.36) | OPRK1OPRM1SIGMAR1GRM5MEN1 | |
| SCHEMBL8269819 | 0.87 | SIGMAR1 (0.34) | SIGMAR1TEAD1KMT2AALDH1A1KCNH2 | |
| SCHEMBL8268962 | 0.86 | MEN1 (0.40) | SIGMAR1MEN1KMT2AALDH1A1KCNH2 | |
| SCHEMBL8268946 | 0.81 | PSEN1 (0.40) | TEAD1CCR2POLB | |
| SCHEMBL13611497 | 0.80 | TEAD1 (0.43) | SIGMAR1TEAD1ALDH1A1KCNH2 | |
| SCHEMBL13513826 | 0.80 | MAPT (0.38) | SIGMAR1ALDH1A1KCNH2SMN1; SMN2 | |
| SCHEMBL8268207 | 0.79 | ACHE (0.37) | TEAD1MEN1KMT2A | |
| SCHEMBL8268947 | 0.79 | PSEN1 (0.42) | TEAD1ALDH1A1SMN1; SMN2 | |
| SCHEMBL13611862 | 0.79 | MCHR1 (0.37) | SIGMAR1HCRTR1 | |
| SCHEMBL13513892 | 0.78 | CHRM4 (0.36) | SIGMAR1TEAD1KMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006043064-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2006-04-27 | — | — | WO | disclosed |