Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13611435 | 0.91 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1SMN1; SMN2SIGMAR1 | |
| SCHEMBL8268948 | 0.86 | OPRK1 (0.33) | MEN1KMT2AALDH1A1SMN1; SMN2SIGMAR1 | |
| SCHEMBL8269819 | 0.85 | SIGMAR1 (0.34) | KMT2AALDH1A1SIGMAR1KCNH2LMNA | |
| SCHEMBL8267625 | 0.81 | FFAR4 (0.39) | — | |
| SCHEMBL13513826 | 0.81 | MAPT (0.38) | ALDH1A1SMN1; SMN2SIGMAR1KDM4EGAA | |
| SCHEMBL8269820 | 0.81 | FFAR4 (0.38) | MEN1KMT2ASIGMAR1CHRM4FAAH | |
| SCHEMBL8268207 | 0.81 | ACHE (0.37) | MEN1KMT2ALMNACHRM4FAAH | |
| SCHEMBL13611497 | 0.80 | TEAD1 (0.43) | ALDH1A1SIGMAR1KDM4EKCNH2LMNA | |
| SCHEMBL13611862 | 0.79 | MCHR1 (0.37) | SIGMAR1DRD4 | |
| SCHEMBL13611493 | 0.78 | NR1H2 (0.41) | DRD4NR1H2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006043064-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2006-04-27 | — | — | WO | disclosed |