Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 7/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8273591 | 0.92 | ADAM17 (0.43) | ADAM17ALDH1A1HTTNAMPTMEN1 | |
| SCHEMBL8273310 | 0.92 | GAA (0.44) | ADAM17ALDH1A1HTTNAMPTMEN1 | |
| SCHEMBL8273592 | 0.91 | HTT (0.46) | CTSSADAM17ALDH1A1HTTNAMPT | |
| SCHEMBL8273588 | 0.89 | ADAM17 (0.40) | ADAM17ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL8223432 | 0.87 | ADAM17 (0.49) | CTSSADAM17CNR2CNR1CTSL | |
| SCHEMBL8273578 | 0.86 | ADAM17 (0.39) | ADAM17ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL8274407 | 0.86 | ADAM17 (0.43) | ADAM17ALDH1A1HTTNAMPTMEN1 | |
| SCHEMBL8273311 | 0.86 | ADAM17 (0.41) | ADAM17ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL8276118 | 0.86 | ADAM17 (0.43) | ADAM17ALDH1A1HTTNAMPTMEN1 | |
| SCHEMBL8273443 | 0.85 | DPP4 (0.41) | ADAM17ALDH1A1HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |