Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.34 |
| ▸ | DPP4 | P27487 | 4/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 6/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8275482 | 0.84 | ADAM17 (0.38) | ADAM17SCN9ADPP4DPP7DPP8 | |
| SCHEMBL16357103 | 0.79 | NAMPT (0.43) | ADAM17SCN9A | |
| SCHEMBL8217853 | 0.79 | NAMPT (0.43) | ADAM17SCN9A | |
| SCHEMBL8273448 | 0.70 | TSHR (0.40) | SCN9A | |
| SCHEMBL8273371 | 0.64 | ADAM17 (0.54) | ADAM17DPP4DPP7DPP8DPP9 | |
| SCHEMBL8213223 | 0.62 | PSEN1 (0.47) | ADAM17 | |
| SCHEMBL8217765 | 0.62 | PSEN1 (0.47) | ADAM17 | |
| SCHEMBL8273446 | 0.62 | ADAM17 (0.38) | ADAM17DPP4DPP7DPP8DPP9 | |
| SCHEMBL8221648 | 0.62 | ADAM17 (0.47) | ADAM17DPP4DPP7DPP8DPP9 | |
| SCHEMBL8274476 | 0.62 | DPP8 (0.53) | ADAM17DPP4DPP7DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |