Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8275946 | 0.91 | NAMPT (0.41) | MEN1KMT2ANAMPTTSHRMTNR1A | |
| SCHEMBL8415324 | 0.88 | ADAM17 (0.47) | MEN1KMT2ANAMPTDRD2ALDH1A1 | |
| SCHEMBL8216981 | 0.88 | MEN1 (0.38) | MEN1KMT2ANAMPTDRD2MTNR1A | |
| SCHEMBL8273743 | 0.84 | ADAM17 (0.46) | MEN1KMT2ANAMPTTSHRNPC1 | |
| SCHEMBL8276821 | 0.83 | ADAM17 (0.42) | MEN1KMT2ANAMPTDRD2ALDH1A1 | |
| SCHEMBL8220841 | 0.83 | MEN1 (0.39) | MEN1KMT2ANAMPTDRD2 | |
| SCHEMBL8213997 | 0.83 | NAMPT (0.37) | MEN1KMT2ANAMPTALOX15MTNR1A | |
| SCHEMBL8217500 | 0.81 | ALDH1A1 (0.50) | MEN1KMT2ANAMPTTSHRLMNA | |
| SCHEMBL8415560 | 0.79 | ADAM17 (0.40) | MEN1KMT2ANAMPTDRD2MTNR1A | |
| SCHEMBL8223675 | 0.79 | DRD2 (0.47) | NAMPTDRD2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |