Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AADAT | Q8N5Z0 | 9/20 | 0.40 |
| ▸ | KYAT1 | Q16773 | 2/20 | 0.40 |
| ▸ | KYAT3 | Q6YP21 | 2/20 | 0.40 |
| ▸ | GOT1 | P17174 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6763756 | 0.78 | AADAT (0.62) | AADATKYAT1KYAT3GOT1 | |
| SCHEMBL8276167 | 0.73 | GAA (0.38) | — | |
| Hydrochloric Acid SCHEMBL6532282 | 0.71 | CYP3A4 (0.39) | AADATKYAT1KYAT3GOT1 | |
| Hydrochloric Acid SCHEMBL4895788 | 0.70 | ADRA2A (0.43) | AADATKYAT1KYAT3GOT1 | |
| SCHEMBL4259135 | 0.70 | ALDH1A1 (0.39) | AADATKYAT1KYAT3GOT1 | |
| SCHEMBL4801630 | 0.70 | AADAT (0.46) | AADATKYAT1KYAT3GOT1CYP1A2 | |
| Hydrochloric Acid SCHEMBL4259133 | 0.70 | ALDH1A1 (0.38) | AADATKYAT1KYAT3GOT1 | |
| SCHEMBL4706317 | 0.68 | ALDH1A1 (0.44) | AADATKYAT1KYAT3GOT1ADORA3 | |
| SCHEMBL8888708 | 0.68 | GSK3B (0.44) | AADATKYAT1KYAT3 | |
| SCHEMBL14275613 | 0.67 | HTT (0.45) | ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080009512-A1 | Tetrahydroquinolones and Aza-Analogues Thereof for Use as Dpp-IV Inhibitors in the Treatment of Diabetes | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | US | disclosed |
| US-20080009512-A1 | Tetrahydroquinolones and Aza-Analogues Thereof for Use as Dpp-IV Inhibitors in the Treatment of Diabetes | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | US | disclosed |
| WO-2005123685-A1 | TETRAHYDROQUINOLONES AND AZA-ANALOGUES THEREOF FOR USE AS DPP-IV INHIBITORS IN THE TREATEMENT OF DIABETES | ASTRAZENECA AB (SE) | 2005-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009512-A1 | Tetrahydroquinolones and Aza-Analogues Thereof for Use as Dpp-IV Inhibitors in the Treatment of Diabetes | DPP4, DPP8, DPP3 | AADAT 1441/4885KYAT1 2886/4885KYAT3 1709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.