SCHEMBL827672

SCHEMBL827672

CCCC(=O)c1ccc2ccoc2c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTNNB1 P35222 8/20 0.56
WNT3A P56704 8/20 0.56
HTR1B P28222 1/20 0.52
HPGD P15428 5/20 0.49
SMN1; SMN2 Q16637 3/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
HSD17B3 P37058 1/20 0.47
NPC1 O15118 4/20 0.42
RAB9A P51151 4/20 0.42
ALDH1A1 P00352 3/20 0.42
KDM4E B2RXH2 1/20 0.41
MAPT P10636 2/20 0.40
HTR3E A5X5Y0 1/20 0.40
HTR3B O95264 1/20 0.40
CHRNB4 P30926 1/20 0.40
CHRNA3 P32297 1/20 0.40
CHRNA7 P36544 1/20 0.40
HTR3A P46098 1/20 0.40
HTR3D Q70Z44 1/20 0.40
HTR3C Q8WXA8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30427249 1.00 CTNNB1 (0.56) CTNNB1WNT3AHTR1BHPGDSMN1; SMN2
SCHEMBL14757925 0.87 CTNNB1 (0.73) CTNNB1WNT3AHTR1BHPGDSMN1; SMN2
SCHEMBL30427297 0.87 CTNNB1 (0.73) CTNNB1WNT3AHTR1BHPGDSMN1; SMN2
SCHEMBL30427164 0.87 HTR1B (0.55) CTNNB1WNT3AHTR1BSMN1; SMN2L3MBTL1
SCHEMBL14135299 0.87 HTR1B (0.55) CTNNB1WNT3AHTR1BSMN1; SMN2L3MBTL1
SCHEMBL24111640 0.80 HTR1B (0.52) CTNNB1WNT3AHTR1BHTR3EHTR3B
SCHEMBL24111708 0.79 HTR1B (0.58) CTNNB1WNT3AHTR1BHTR3EHTR3B
SCHEMBL23330466 0.79 CTNNB1 (0.40) CTNNB1WNT3AHTR1BHPGDSMN1; SMN2
SCHEMBL26958041 0.79 HSD17B3 (0.61) HPGDSMN1; SMN2L3MBTL1HSD17B3NPC1
SCHEMBL103577 0.78 HTR1B (0.59) CTNNB1WNT3AHTR1BHPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11767305-B2 Advantageous benzofuran compositions for mental disorders or enhancement TACTOGEN INC (US) 2023-09-26 US disclosed
US-11767305-B2 Advantageous benzofuran compositions for mental disorders or enhancement TACTOGEN INC (US) 2023-09-26 US disclosed
WO-2023107653-A2 BENZOFURAN SALT MORPHIC FORMS AND MIXTURES FOR THE TREATMENT OF MENTAL DISORDERS OR MENTAL ENHANCEMENT TACTOGEN INC (US) 2023-06-15 WO disclosed
WO-2023107715-A1 SPECIALIZED COMBINATIONS FOR MENTAL DISORDERS OR MENTAL ENHANCEMENT TACTOGEN INC (US) 2023-06-15 WO disclosed
US-20230150963-A1 ADVANTAGEOUS BENZOFURAN COMPOSITIONS FOR MENTAL DISORDERS OR ENHANCEMENT TACTOGEN INC. (US) 2023-05-18 US disclosed
US-20230150963-A1 ADVANTAGEOUS BENZOFURAN COMPOSITIONS FOR MENTAL DISORDERS OR ENHANCEMENT TACTOGEN INC. (US) 2023-05-18 US disclosed
CN-116075300-A Advantageous benzofuran compositions for mental disorders or mental enhancement 泰科根公司 2023-05-05 CN disclosed
WO-2021252538-A2 ADVANTAGEOUS BENZOFURAN COMPOSITIONS FOR MENTAL DISORDERS OR ENHANCEMENT TACTOGEN INC (US) 2021-12-16 WO disclosed
US-8507680-B2 Production process of a heteroaryl-type boron compounds with iridium catalyst MITSUBISHI RAYON CO., LTD. (JP) 2013-08-13 US disclosed
US-20120142924-A1 PRODUCTION PROCESS OF A HETEROARYL-TYPE BORON COMPOUNDS WITH IRIDIUM CATALYST MITSUBISHI RAYON CO., LTD. (JP) 2012-06-07 US disclosed
US-8143407-B2 Process for production of heteroaryl-type boron compounds with iridium catalyst MITSUBISHI RAYON CO., LTD. (JP) 2012-03-27 US disclosed
EP-1481978-B1 PROCESS FOR PRODUCTION OF HETEROARYL-TYPE BORON COMPOUNDS WITH IRIDIUM CATALYST MITSUBISHI RAYON CO (JP) 2011-09-14 EP disclosed
US-20100010224-A1 PROCESS FOR PRODUCTION OF HETEROARYL-TYPE BORON COMPOUNDS WITH IRIDIUM CATALYST MITSUBISHI RAYON CO., LTD. (JP) 2010-01-14 US disclosed
US-7612218-B2 Process for production of heteroaryl-type boron compounds with iridium catalyst MITSUBISHI RAYON CO., LTD. (JP) 2009-11-03 US disclosed
US-20050148775-A1 Process for production of heteroaryl-type boron compounds with iridium catalyst MITSUBISHI RAYON CO., LTD. (JP) 2005-07-07 US disclosed
EP-1481978-A1 PROCESS FOR PRODUCTION OF HETEROARYL-TYPE BORON COMPOUNDS WITH IRIDIUM CATALYST Mitsubishi Rayon Co., Ltd. (JP) 2004-12-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11767305-B2 Advantageous benzofuran compositions for mental disorders or enhancement BDNF, CREBBP, ELF3 CTNNB1 2504/4885WNT3A 3773/4885HTR1B 273/4885
US-20230150963-A1 ADVANTAGEOUS BENZOFURAN COMPOSITIONS FOR MENTAL DISORDERS OR ENHANCEMENT BDNF, CREBBP, ELF3 CTNNB1 2504/4885WNT3A 3773/4885HTR1B 273/4885
US-20100010224-A1 PROCESS FOR PRODUCTION OF HETEROARYL-TYPE BORON COMPOUNDS WITH IRIDIUM CATALYST PIN4, IPO5, HLCS CTNNB1 3662/4885WNT3A 1951/4885HTR1B 3539/4885
US-20120142924-A1 PRODUCTION PROCESS OF A HETEROARYL-TYPE BORON COMPOUNDS WITH IRIDIUM CATALYST PIN4, NISCH, HLCS CTNNB1 3056/4885WNT3A 1261/4885HTR1B 3596/4885
US-20050148775-A1 Process for production of heteroaryl-type boron compounds with iridium catalyst PIN4, IPO5, HLCS CTNNB1 3662/4885WNT3A 1951/4885HTR1B 3539/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.