Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 2/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13896394 | 0.93 | POLB (0.40) | POLBALDH1A1MAPTTDP1LMNA | |
| SCHEMBL8278885 | 0.91 | ADRB3 (0.33) | POLBALDH1A1MAPTTDP1LMNA | |
| SCHEMBL3973079 | 0.87 | ADRB3 (0.41) | POLBALDH1A1MAPTTDP1LMNA | |
| SCHEMBL3973076 | 0.87 | ADRB3 (0.41) | POLBALDH1A1MAPTTDP1LMNA | |
| SCHEMBL3973077 | 0.87 | ADRB3 (0.41) | POLBALDH1A1MAPTTDP1LMNA | |
| SCHEMBL8294160 | 0.85 | DRD2 (0.35) | POLBALDH1A1MAPTTDP1LMNA | |
| SCHEMBL8295392 | 0.84 | ALDH1A1 (0.33) | POLBALDH1A1MAPTTDP1LMNA | |
| SCHEMBL3968794 | 0.83 | CTSB (0.37) | — | |
| SCHEMBL8277058 | 0.83 | CTSB (0.37) | — | |
| SCHEMBL13623487 | 0.81 | ADRB3 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005095403-A2 | MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION | INTERMUNE, INC. (US) | 2005-10-13 | — | — | WO | disclosed |
| WO-2005037214-A2 | MACROCYCLIC CARBOXYLIC ACIDS AND ACYLSULFONAMIDES AS INHIBITORS OF HCV REPLICATION | INTERMUNE, INC. (US) | 2005-04-28 | — | — | WO | disclosed |