Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8278996 | 0.86 | ALDH1A1 (0.62) | ALDH1A1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL12562041 | 0.84 | MAPT (0.59) | ALDH1A1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL10940028 | 0.83 | MAPT (0.57) | ALDH1A1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL10942052 | 0.83 | MAPT (0.57) | ALDH1A1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1285585 | 0.82 | NPC1 (0.61) | ALDH1A1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11848975 | 0.82 | MAPT (0.60) | ALDH1A1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL10604485 | 0.82 | MAPT (0.64) | ALDH1A1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL223451 | 0.81 | MAPT (0.63) | ALDH1A1MAPTRAB9ANPC1MEN1 | |
| SCHEMBL8947150 | 0.81 | GAA (0.67) | ALDH1A1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3955088 | 0.80 | MAPT (0.62) | ALDH1A1MAPTRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902330-B2 | Protein kinase inhibitors and methods for identifying same | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2011-03-08 | — | — | US | disclosed |
| US-7902330-B2 | Protein kinase inhibitors and methods for identifying same | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2011-03-08 | — | — | US | disclosed |
| US-20070254312-A1 | Protein Kinase Inhibitors and Methods for Identiying Same | NATIONAL INSTITUTES OF HEALTH | 2007-11-01 | — | — | US | disclosed |
| US-20070254312-A1 | Protein Kinase Inhibitors and Methods for Identiying Same | NATIONAL INSTITUTES OF HEALTH | 2007-11-01 | — | — | US | disclosed |
| WO-2005079300-A2 | PROTEIN KINASE INHIBITORS AND METHODS FOR IDENTIFYING SAME | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2005-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254312-A1 | Protein Kinase Inhibitors and Methods for Identiying Same | PRKCA, PRKCE, PRKCB | ALDH1A1 4408/4885MAPT 3466/4885RAB9A 2011/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.