Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | MPL | P40238 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22130225 | 0.87 | KIT (0.41) | HSD17B10LMNAMAPTCYP2C9CYP2C19 | |
| SCHEMBL2666284 | 0.83 | MEN1 (0.40) | CYP2C9CYP2C19MAP4K4NPC1RAB9A | |
| SCHEMBL3342664 | 0.83 | RAB9A (0.44) | HSD17B10LMNAMAPTTDP1NPC1 | |
| SCHEMBL8226435 | 0.81 | RXRA (0.44) | NPC1RAB9AIRAK4TGFBR1MEN1 | |
| SCHEMBL12021925 | 0.81 | MEN1 (0.34) | NPC1RAB9AIRAK4ALOX5APFEN1 | |
| SCHEMBL2666270 | 0.81 | KMO (0.47) | MAPTTP53SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8221626 | 0.78 | GRIN2B (0.35) | NPC1RAB9AIRAK4ALOX5APFEN1 | |
| SCHEMBL2666243 | 0.77 | KMO (0.47) | GRM5 | |
| SCHEMBL22578238 | 0.77 | CYP1A2 (0.47) | HSD17B10LMNAMAPTNPC1RAB9A | |
| SCHEMBL10864552 | 0.77 | IRAK4 (0.39) | HSD17B10CYP2C9CYP2C19TDP1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745047-B1 | PYRAZOLO[4,3-E]-1,2,4-TRIAZOLO[1,5-C]PYRIMIDINE ADENOSINE-A2A- RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2010-03-24 | — | — | EP | disclosed |
| WO-2005103055-A1 | PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO-[1,5-c]-PYRIMIDINE ADENOSINE A2A RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 2005-11-03 | — | — | WO | disclosed |