Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | GLS | O94925 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14192408 | 0.86 | KAT8 (0.69) | KAT8GAAMAPTGLSATM | |
| SCHEMBL12354953 | 0.83 | KAT8 (0.65) | KAT8GAAMAPTGLSATM | |
| SCHEMBL8832776 | 0.83 | KAT8 (0.74) | KAT8GAAMAPTGLSPOLB | |
| SCHEMBL27571956 | 0.82 | ATM (0.63) | KAT8GAAMAPTGLSATM | |
| SCHEMBL28759581 | 0.82 | ATM (0.67) | KAT8GAAMAPTGLSATM | |
| SCHEMBL5629418 | 0.80 | RAB9A (0.68) | KAT8GAAMAPTGLSATM | |
| SCHEMBL29353446 | 0.80 | KAT8 (0.61) | KAT8GAAMAPTGLSATM | |
| SCHEMBL21443364 | 0.80 | GLS (0.59) | GLS | |
| SCHEMBL6374673 | 0.79 | KAT8 (0.60) | KAT8GAAMAPTGLSATM | |
| SCHEMBL5629412 | 0.79 | ATM (0.63) | KAT8GAAMAPTGLSATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005072731-A1 | 3-PHENYL-N- ((1, 3, 4) THIADIAZOL-2-YL) -ACRYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF ESTROGEN-RELATED RECEPTORS FOR THE TREATMENT OF E.G. CANCER, RHEUMATOID ARTHRITIS OR NEUROLOGICAL DISORDERS | X-CEPTOR THERAPEUTICS, INC. (US) | 2005-08-11 | — | — | WO | disclosed |