SCHEMBL8282193

SCHEMBL8282193

CC(C)CN1C(=O)CC(C)(C)CC1=O

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 5/20 0.40
PIK3CD O00329 4/20 0.40
DRD2 P14416 2/20 0.40
HTR2C P28335 1/20 0.40
HTR7 P34969 1/20 0.40
HRH1 P35367 1/20 0.40
HTR2B P41595 1/20 0.40
GAA P10253 1/20 0.38
ALDH1A1 P00352 1/20 0.37
HTR2A P28223 1/20 0.36
MAPT P10636 1/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
TSHR P16473 1/20 0.35
DRD3 P35462 1/20 0.35
MMP2 P08253 1/20 0.34
MMP3 P08254 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8283898 0.83 GAA (0.39) PIK3CDGAAALDH1A1MEN1KMT2A
SCHEMBL8294610 0.83 PIK3CD (0.39) PIK3CDGAAALDH1A1MEN1KMT2A
SCHEMBL8282191 0.82 KDM4E (0.45) HTR1APIK3CDDRD2HTR2CHRH1
SCHEMBL8282203 0.81 PIK3CD (0.38) HTR1APIK3CDDRD2GAAALDH1A1
SCHEMBL8282199 0.79 PIK3CD (0.38) PIK3CDGAAALDH1A1MEN1KMT2A
SCHEMBL8282902 0.78 HTR1A (0.43) HTR1APIK3CDDRD2DRD3
SCHEMBL1682032 0.77 PIK3CD (0.50) PIK3CDGAAALDH1A1MEN1KMT2A
SCHEMBL12148577 0.77 GAA (0.50) PIK3CDGAAALDH1A1MAPTMEN1
SCHEMBL8283572 0.76 MEN1 (0.38) PIK3CDGAAALDH1A1MEN1KMT2A
SCHEMBL8080232 0.75 HTR1A (0.36) HTR1ADRD2HTR2CHTR7HRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3204355-B1 PHOTOSTABLE COMPOUNDS, ABSORBING COMPOUNDS AND USES THEREOF COMMW SCIENT IND RES ORG (AU) 2022-06-22 EP disclosed
EP-3022180-B1 UV ABSORBING COMPOUNDS, COMPOSITIONS COMPRISING SAME AND USES THEREOF CORAL SUNSCREEN PTY LTD (AU) 2022-02-23 EP disclosed
EP-3022180-B1 UV ABSORBING COMPOUNDS, COMPOSITIONS COMPRISING SAME AND USES THEREOF CORAL SUNSCREEN PTY LTD (AU) 2022-02-23 EP disclosed
US-10315994-B2 Photostable compounds, absorbing compounds and uses thereof COMMOMWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION (AU) 2019-06-11 US disclosed
US-20180155288-A1 UV Absorbing Compounds, Compositions Comprising Same and Uses Thereof CORAL SUNSCREEN PTY LTD (AU) 2018-06-07 US disclosed
US-20180155288-A1 UV Absorbing Compounds, Compositions Comprising Same and Uses Thereof CORAL SUNSCREEN PTY LTD (AU) 2018-06-07 US disclosed
US-20180155288-A1 UV Absorbing Compounds, Compositions Comprising Same and Uses Thereof CORAL SUNSCREEN PTY LTD (AU) 2018-06-07 US disclosed
US-9920009-B2 UV absorbing compounds, compositions comprising same and uses thereof CORAL SUNSCREEN PTY LTD (AU) 2018-03-20 US disclosed
US-9920009-B2 UV absorbing compounds, compositions comprising same and uses thereof CORAL SUNSCREEN PTY LTD (AU) 2018-03-20 US disclosed
US-9920009-B2 UV absorbing compounds, compositions comprising same and uses thereof CORAL SUNSCREEN PTY LTD (AU) 2018-03-20 US disclosed
US-20100074867-A1 P1-NONEPIMERIZABLE KETOAMIDE INHIBITORS OF HCV NS3 PROTEASE Schering Corporation Patent Department, K-6-1; 1990 (US) 2010-03-25 US disclosed
US-7619094-B2 Ketoamides with cyclic P4's as inhibitors of NS3 serine protease of hepatitis C virus SCHERING CORPORATION (US) 2009-11-17 US disclosed
US-7449447-B2 Peptidomimetic NS3-serine protease inhibitors of hepatitis C virus SCHERING CORPORATION (US) 2008-11-11 US disclosed
US-20070093430-A1 Novel ketoamides with cyclic P4's as inhibitors of NS3 serine protease of hepatitis C virus MERCK SHARP & DOHME CORP. 2007-04-26 US disclosed
US-7173057-B2 Ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus SCHERING CORPORATION (US) 2007-02-06 US disclosed
US-7173057-B2 Ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus SCHERING CORPORATION (US) 2007-02-06 US disclosed
WO-2005085242-A1 NOVEL KETOAMIDES WITH CYCLIC P4'S AS INHIBITORS OF NS3 SERINE PROTEASE OF HEPATITIS C VIRUS SCHERING CORPORATION (US) 2005-09-15 WO disclosed
WO-2005021584-A2 NOVEL PEPTIDOMIMETIC NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS SCHERING CORPORATION (US) 2005-03-10 WO disclosed
EP-0462123-B1 UV-ABSORBING COMPOUNDS AND COMPOSITIONS AUSTRALIAN INST MARINE SCIENCE (AU) 1997-09-24 EP disclosed
US-5637718-A 1,4,5,6-TETRAHYDROPYRIDINE DERIVATIVES ICI AUSTRALIA OPERATIONS PROPRIETARY LTD. (AU) 1997-06-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100074867-A1 P1-NONEPIMERIZABLE KETOAMIDE INHIBITORS OF HCV NS3 PROTEASE CTRL, PREP, CES1 HTR1A 1305/4885PIK3CD 1495/4885DRD2 4614/4885
US-20180155288-A1 UV Absorbing Compounds, Compositions Comprising Same and Uses Thereof ERCC1, ERCC4, ERCC5 HTR1A 4664/4885PIK3CD 4199/4885DRD2 4484/4885
US-20070093430-A1 Novel ketoamides with cyclic P4's as inhibitors of NS3 serine protease of hepatitis C virus PREP, PRSS1, P4HB HTR1A 4258/4885PIK3CD 850/4885DRD2 4840/4885
US-10315994-B2 Photostable compounds, absorbing compounds and uses thereof PCNA, SLC19A1, ERCC4 HTR1A 3943/4885PIK3CD 4761/4885DRD2 1584/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.