Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.73 |
| ▸ | LMNA | P02545 | 3/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | NPBWR1 | P48145 | 9/20 | 0.60 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.60 |
| ▸ | ATM | Q13315 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.43 |
| ▸ | GPR183 | P32249 | 1/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15380494 | 0.88 | SMN1; SMN2 (0.64) | SMN1; SMN2LMNANPSR1NPBWR1MCHR1 | |
| SCHEMBL16901934 | 0.81 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNANPSR1NPBWR1MCHR1 | |
| SCHEMBL15566993 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNANPSR1NPBWR1MCHR1 | |
| SCHEMBL15566368 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNANPSR1NPBWR1MCHR1 | |
| SCHEMBL13694257 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNANPSR1NPBWR1MCHR1 | |
| SCHEMBL10849726 | 0.79 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNANPSR1NPBWR1MCHR1 | |
| SCHEMBL15596841 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNANPSR1NPBWR1MCHR1 | |
| SCHEMBL21511152 | 0.77 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNANPSR1NPBWR1MCHR1 | |
| SCHEMBL16901881 | 0.76 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNANPSR1NPBWR1MCHR1 | |
| SCHEMBL21442499 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNANPSR1NPBWR1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005077915-A1 | PYRIDAZINONES AS ANTAGONISTS OF A4 INTEGRINS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-08-25 | — | — | WO | disclosed |