Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | TSPO | P30536 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14003034 | 0.91 | KDM4E (0.39) | KDM4EALDH1A1HPGDUSP2HSD17B10 | |
| SCHEMBL13932114 | 0.85 | KDM4E (0.43) | KDM4EALDH1A1HPGDUSP2HSD17B10 | |
| SCHEMBL8284750 | 0.85 | KDM4E (0.38) | KDM4EALDH1A1HPGDUSP2HSD17B10 | |
| SCHEMBL4284545 | 0.85 | KDM4E (0.37) | KDM4EALDH1A1HPGDUSP2HSD17B10 | |
| SCHEMBL8284613 | 0.83 | KDM4E (0.41) | KDM4EALDH1A1HPGDUSP2HSD17B10 | |
| SCHEMBL4281670 | 0.83 | KDM4E (0.36) | KDM4EALDH1A1HPGDUSP2HSD17B10 | |
| SCHEMBL4280686 | 0.82 | P2RX3 (0.34) | KDM4EALDH1A1GFER | |
| SCHEMBL8285106 | 0.82 | SOS1 (0.45) | KDM4EALDH1A1HPGDUSP2HSD17B10 | |
| SCHEMBL8285627 | 0.82 | KDM4E (0.33) | KDM4EALDH1A1HPGDUSP2HSD17B10 | |
| SCHEMBL4280018 | 0.81 | P2RX3 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697345-B1 | MORPHOLINYL CONTAINING BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION | TIBOTEC PHARM LTD (IE) | 2008-03-12 | — | — | EP | disclosed |
| WO-2005058871-A1 | MORPHOLINYL CONTAINING BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2005-06-30 | — | — | WO | disclosed |