Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | TP53 | P04637 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8284114 | 0.94 | HSD17B10 (0.33) | LMNASMN1; SMN2HSD17B10MAPTTSHR | |
| SCHEMBL14507994 | 0.92 | SMN1; SMN2 (0.34) | LMNASMN1; SMN2HSD17B10MAPTTSHR | |
| SCHEMBL8284127 | 0.88 | LMNA (0.34) | LMNASMN1; SMN2HSD17B10MAPTTSHR | |
| SCHEMBL8284130 | 0.84 | CTSS (0.43) | — | |
| SCHEMBL8284595 | 0.84 | SMN1; SMN2 (0.33) | LMNASMN1; SMN2HSD17B10MAPTL3MBTL1 | |
| SCHEMBL14507993 | 0.80 | SMN1; SMN2 (0.35) | LMNASMN1; SMN2HSD17B10MAPTTSHR | |
| SCHEMBL14507990 | 0.79 | CTSK (0.40) | LMNASMN1; SMN2HSD17B10RAB9AALDH1A1 | |
| SCHEMBL8284106 | 0.79 | LMNA (0.32) | LMNASMN1; SMN2HSD17B10MAPTTSHR | |
| SCHEMBL14507992 | 0.78 | LMNA (0.32) | LMNASMN1; SMN2HSD17B10MAPTTSHR | |
| SCHEMBL8284132 | 0.75 | RAB9A (0.36) | LMNASMN1; SMN2HSD17B10MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063742-A2 | AMIDINO COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | disclosed |