Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6280812 | 0.85 | HIF1A (0.54) | HIF1AADRB1ADRA1AADRB2HTR1A | |
| SCHEMBL16096523 | 0.85 | HIF1A (0.54) | HIF1AADRB1ADRA1AADRB2HTR1A | |
| SCHEMBL16937735 | 0.84 | HIF1A (0.50) | HIF1AADRB1ADRA1AADRB2HTR1A | |
| SCHEMBL6406993 | 0.84 | HIF1A (0.50) | HIF1AADRB1ADRA1AADRB2HTR1A | |
| Hydrochloric Acid SCHEMBL4739557 | 0.84 | LMNA (0.56) | HIF1AADRB1ADRA1AADRB2HTR1A | |
| SCHEMBL3870141 | 0.80 | HIF1A (0.49) | HIF1AADRB1ADRA1AADRB2HTR1A | |
| SCHEMBL9054645 | 0.80 | OPRK1 (0.50) | HIF1AADRB1ADRA1AADRB2HTR1A | |
| SCHEMBL21507929 | 0.79 | KDM4E (0.41) | TSHRLMNAKDM4EALDH1A1CYP3A4 | |
| SCHEMBL13075267 | 0.79 | ACHE (0.41) | ALDH1A1CYP3A4 | |
| SCHEMBL7107685 | 0.78 | HIF1A (0.47) | HIF1AADRB1ADRA1AADRB2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005058892-A1 | PYRAZOLO [3,4-B] PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-06-30 | — | — | WO | disclosed |