Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 4/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285115 | 0.88 | BPTF (0.36) | EGFRMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL8285126 | 0.88 | PDE11A (0.36) | FLT3EGFRMAPTMEN1KMT2A | |
| SCHEMBL5872062 | 0.83 | PDE11A (0.44) | MAPTALDH1A1SMN1; SMN2MAPK1LMNA | |
| SCHEMBL8287909 | 0.82 | MAPT (0.44) | MAPTCYP1A2MEN1KMT2AALDH1A1 | |
| SCHEMBL5871610 | 0.77 | MEN1 (0.43) | MAPK9FLT3EGFRMAPTCYP1A2 | |
| SCHEMBL8287325 | 0.77 | GAA (0.42) | MAPTCYP1A2CYP3A4ALDH1A1SMN1; SMN2 | |
| SCHEMBL5872005 | 0.76 | MAT2A (0.43) | MAPK9CYP1A2CYP3A4MEN1KMT2A | |
| SCHEMBL8287837 | 0.76 | MAT2A (0.54) | MAPK9MAPTCYP1A2CYP3A4MEN1 | |
| SCHEMBL8287801 | 0.75 | ALDH1A2 (0.37) | MAPTKMT2AALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL8286343 | 0.73 | ADORA1 (0.43) | MAPTSMN1; SMN2TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |