Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286059 | 0.89 | PDE11A (0.45) | PDE11AALDH1A1KDM4EGAAPRKDC | |
| SCHEMBL8286367 | 0.87 | PDE11A (0.73) | PDE11AALDH1A1KDM4EGAAPRKDC | |
| SCHEMBL8286344 | 0.85 | PDE11A (0.64) | PDE11AALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL8286346 | 0.85 | PDE11A (0.61) | PDE11AALDH1A1KDM4EGAAHPGD | |
| SCHEMBL5872109 | 0.84 | PDE11A (0.75) | PDE11AALDH1A1KDM4EGAAHPGD | |
| SCHEMBL8285166 | 0.84 | PDE11A (0.60) | PDE11AALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL8286342 | 0.84 | PDE11A (0.60) | PDE11AALDH1A1KDM4EGAANPSR1 | |
| SCHEMBL5871598 | 0.82 | PDE11A (0.58) | PDE11AALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL5871831 | 0.81 | PDE11A (0.57) | PDE11AALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL8286347 | 0.80 | PDE11A (0.54) | PDE11AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |