Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.73 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | GAK | O14976 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286093 | 0.90 | PDE11A (0.59) | PDE11APRKDCSYKALDH1A1PIK3CA | |
| SCHEMBL8286388 | 0.89 | PDE11A (0.58) | PDE11APRKDCSYKALDH1A1HSD17B10 | |
| SCHEMBL8285153 | 0.87 | PDE11A (0.54) | PDE11APRKDCALDH1A1HSD17B10KDM4E | |
| SCHEMBL8287579 | 0.85 | PDE11A (0.58) | PDE11ASYKALDH1A1HSD17B10KDM4E | |
| SCHEMBL8286364 | 0.85 | PDE11A (0.87) | PDE11AHSD17B10KDM4EHPGDMAPT | |
| SCHEMBL8285154 | 0.84 | PDE11A (1.00) | PDE11AKDM4ENPSR1PIK3CAPIK3CD | |
| SCHEMBL8285158 | 0.84 | PDE11A (0.80) | PDE11AALDH1A1HSD17B10KDM4ETDP1 | |
| SCHEMBL5871369 | 0.84 | PDE11A (0.82) | PDE11APRKDCALDH1A1GAANPSR1 | |
| SCHEMBL8285151 | 0.83 | PDE11A (0.80) | PDE11AALDH1A1HSD17B10MAPT | |
| SCHEMBL8287889 | 0.80 | PDE11A (0.73) | PDE11ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |