Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 1.00 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286364 | 0.93 | PDE11A (0.87) | PDE11APIK3CBPIK3CDPIK3CALMNA | |
| SCHEMBL5871369 | 0.90 | PDE11A (0.82) | PDE11APIK3CBPIK3CDPIK3CANPSR1 | |
| SCHEMBL8287391 | 0.90 | PDE11A (0.81) | PDE11APIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL8285151 | 0.89 | PDE11A (0.80) | PDE11ATP53PTK2CLK4LMNA | |
| SCHEMBL8285158 | 0.89 | PDE11A (0.80) | PDE11ATP53PTK2CLK4KDM4E | |
| SCHEMBL8286385 | 0.88 | PDE11A (0.79) | PDE11APIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL8287152 | 0.85 | PDE11A (0.75) | PDE11AKDM4E | |
| SCHEMBL5872109 | 0.85 | PDE11A (0.75) | PDE11APIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL8285260 | 0.85 | PDE11A (0.73) | PDE11ANPSR1LMNAHTTKDM4E | |
| SCHEMBL8287889 | 0.84 | PDE11A (0.73) | PDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |