Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.80 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 3/20 | 0.40 |
| ▸ | CCND3 | P30281 | 2/20 | 0.40 |
| ▸ | CCND1 | P24385 | 2/20 | 0.40 |
| ▸ | CCND2 | P30279 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | MAT2A | P31153 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286364 | 0.93 | PDE11A (0.87) | PDE11AMETCDK4CCND3CCND1 | |
| SCHEMBL5871369 | 0.90 | PDE11A (0.82) | PDE11AALDH1A1SMN1; SMN2TP53MAPT | |
| SCHEMBL8285151 | 0.89 | PDE11A (0.80) | PDE11ACDK4CCND3CCND1CCND2 | |
| SCHEMBL8285154 | 0.89 | PDE11A (1.00) | PDE11AKDM4EPTK2CLK4TP53 | |
| SCHEMBL8287152 | 0.87 | PDE11A (0.75) | PDE11ADRD2ALDH1A1TSHRKDM4E | |
| SCHEMBL8285166 | 0.87 | PDE11A (0.60) | PDE11ACDK4CCND3CCND1CCND2 | |
| SCHEMBL8285260 | 0.87 | PDE11A (0.73) | PDE11ACYP1A2ALDH1A1CYP2C19HSD17B10 | |
| SCHEMBL8287889 | 0.86 | PDE11A (0.73) | PDE11AHRH4 | |
| SCHEMBL8287175 | 0.85 | PDE11A (0.69) | PDE11ADRD2KDM4ESMN1; SMN2MAPT | |
| SCHEMBL8286367 | 0.84 | PDE11A (0.73) | PDE11AALDH1A1TSHRHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |