Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.87 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 2/20 | 0.36 |
| ▸ | CCND1 | P24385 | 2/20 | 0.36 |
| ▸ | CCND2 | P30279 | 2/20 | 0.36 |
| ▸ | CCND3 | P30281 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GALR2 | O43603 | 1/20 | 0.35 |
| ▸ | GALR1 | P47211 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | WEE1 | P30291 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285154 | 0.93 | PDE11A (1.00) | PDE11ALMNAPIK3CDPIK3CAPIK3CB | |
| SCHEMBL8285158 | 0.93 | PDE11A (0.80) | PDE11AMAPTCDK4CCND1CCND2 | |
| SCHEMBL5871369 | 0.93 | PDE11A (0.82) | PDE11AMAPTLMNAPIK3CDPIK3CA | |
| SCHEMBL8285151 | 0.91 | PDE11A (0.80) | PDE11AMAPTLMNACDK4CCND1 | |
| SCHEMBL8287152 | 0.90 | PDE11A (0.75) | PDE11AKDM4ETSHR | |
| SCHEMBL8285260 | 0.89 | PDE11A (0.73) | PDE11AMAPTLMNAKDM4EHTT | |
| SCHEMBL8287889 | 0.87 | PDE11A (0.73) | PDE11A | |
| SCHEMBL8287175 | 0.86 | PDE11A (0.69) | PDE11AMAPTLMNAKDM4EHTT | |
| SCHEMBL8286367 | 0.85 | PDE11A (0.73) | PDE11AMAPTPIK3CDPIK3CAPIK3CB | |
| SCHEMBL8287179 | 0.85 | PDE11A (0.70) | PDE11AMAPTLMNAHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |