Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.75 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | CASP5 | P51878 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | CASP4 | P49662 | 1/20 | 0.37 |
| ▸ | GPR6 | P46095 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286364 | 0.90 | PDE11A (0.87) | PDE11ATSHRKDM4E | |
| SCHEMBL8285158 | 0.87 | PDE11A (0.80) | PDE11ACASP1TSHRALDH1A1KDM4E | |
| SCHEMBL5871369 | 0.87 | PDE11A (0.82) | PDE11AALDH1A1 | |
| SCHEMBL8285151 | 0.85 | PDE11A (0.80) | PDE11ACASP1KDM1AALDH1A1HTR2C | |
| SCHEMBL8285154 | 0.85 | PDE11A (1.00) | PDE11AKDM4E | |
| SCHEMBL8285260 | 0.83 | PDE11A (0.73) | PDE11AALDH1A1KDM4EFAAHTRPV1 | |
| SCHEMBL8287175 | 0.82 | PDE11A (0.69) | PDE11AHSD11B1KDM4EDRD2DRD3 | |
| SCHEMBL8287172 | 0.82 | PDE11A (0.66) | PDE11AALDH1A1KDM4EL3MBTL1DRD2 | |
| SCHEMBL8287889 | 0.81 | PDE11A (0.73) | PDE11A | |
| SCHEMBL8286367 | 0.80 | PDE11A (0.73) | PDE11ATSHRALDH1A1KDM4EATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |