SCHEMBL8285178

SCHEMBL8285178

COCCNc1nc2c(cc1F)c(=O)cc(Nc1ccccc1)n2-c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH3 Q9ULD8 3/20 0.41
CYP1A2 P05177 6/20 0.38
CYP3A4 P08684 6/20 0.38
ALDH1A1 P00352 4/20 0.38
CYP2C19 P33261 4/20 0.38
USP2 O75604 3/20 0.38
ALOX15 P16050 3/20 0.38
CLK4 Q9HAZ1 3/20 0.38
APEX1 P27695 1/20 0.38
CASP7 P55210 1/20 0.38
PDE11A Q9HCR9 1/20 0.38
HSD17B10 Q99714 2/20 0.37
CYP2D6 P10635 2/20 0.37
MAPK1 P28482 1/20 0.37
MAPT P10636 2/20 0.37
THRB P10828 1/20 0.37
BCDIN3D Q7Z5W3 1/20 0.36
ALDH1A2 O94788 1/20 0.36
ALDH1A3 P47895 1/20 0.36
CSNK2A1 P68400 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8285182 0.83 PDE11A (0.39) CYP1A2CYP3A4ALDH1A1USP2CLK4
SCHEMBL5872005 0.81 MAT2A (0.43) CYP1A2CYP3A4ALDH1A1CYP2C19USP2
SCHEMBL8285203 0.80 PDE11A (0.41) KCNH3CYP1A2CYP3A4ALDH1A1CYP2C19
SCHEMBL5872009 0.79 PDE11A (0.44) CYP1A2CYP3A4ALDH1A1CYP2C19USP2
SCHEMBL5871661 0.79 PDE11A (0.42) CYP1A2CYP3A4ALDH1A1PDE11AMAPK1
SCHEMBL8287374 0.78 PDE11A (0.40) ALDH1A1PDE11AMAPTALDH1A2ALDH1A3
SCHEMBL5872062 0.77 PDE11A (0.44) ALDH1A1PDE11AMAPK1MAPTALDH1A2
SCHEMBL8285172 0.76 PDE11A (0.40) ALDH1A1PDE11AMAPK1ALDH1A2ALDH1A3
SCHEMBL8287521 0.76 PDE11A (0.40) CYP1A2ALDH1A1PDE11AMAPK1ALDH1A2
SCHEMBL8286423 0.76 KCNH3 (0.42) KCNH3CYP1A2CYP3A4ALDH1A1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005091857-A2 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS BAYER PHARMACEUTICALS CORPORATION (US) 2005-10-06 WO disclosed
WO-2003027112-A1 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS BAYER PHARMACEUTICALS CORPORATION (US) 2003-04-03 WO disclosed