Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | KCNH3 | Q9ULD8 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | GLA | P06280 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 4/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 3/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285178 | 0.80 | KCNH3 (0.41) | PDE11ACFTRKCNH3MAPTALDH1A1 | |
| SCHEMBL8285184 | 0.79 | PDE11A (0.47) | PDE11AMAPTALDH1A1KDM4ELMNA | |
| SCHEMBL8285202 | 0.79 | NCF1 (0.47) | PDE11ACFTRKCNH3MAPTALDH1A1 | |
| SCHEMBL8287857 | 0.76 | PDE11A (0.56) | PDE11ACFTRKCNH3MAPTALDH1A1 | |
| SCHEMBL8286423 | 0.75 | KCNH3 (0.42) | PDE11ACFTRKCNH3MAPTALDH1A1 | |
| SCHEMBL8287127 | 0.75 | PDE11A (0.59) | PDE11ACFTRMAPTALDH1A1KDM4E | |
| SCHEMBL8285209 | 0.75 | PDE11A (0.43) | PDE11AALDH1A1KDM4EHPGDGAA | |
| SCHEMBL8285217 | 0.73 | PDE11A (0.46) | PDE11AMAPTALDH1A1KDM4ELMNA | |
| SCHEMBL8286379 | 0.72 | PDE11A (0.43) | PDE11AALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL8285140 | 0.71 | KCNH3 (0.44) | PDE11ACFTRKCNH3MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |