Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.55 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | MAT2A | P31153 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | WEE1 | P30291 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.32 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285257 | 0.90 | PDE11A (0.57) | PDE11ACNR1CNR2KMT2AMEN1 | |
| SCHEMBL8285254 | 0.90 | PDE11A (0.59) | PDE11ACNR1CNR2KMT2AMEN1 | |
| SCHEMBL8285280 | 0.89 | PDE11A (0.56) | PDE11ACNR1CNR2KMT2AMEN1 | |
| SCHEMBL8362903 | 0.89 | PDE11A (0.56) | PDE11ACNR1CNR2MAT2AKMT2A | |
| SCHEMBL8285263 | 0.88 | PDE11A (0.56) | PDE11ACNR1CNR2KMT2AMEN1 | |
| SCHEMBL8287845 | 0.86 | PDE11A (0.55) | PDE11ACNR1CNR2MAT2AKMT2A | |
| SCHEMBL8285266 | 0.84 | PDE11A (0.57) | PDE11AKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL8287168 | 0.83 | PDE11A (0.56) | PDE11A | |
| SCHEMBL8287106 | 0.83 | PDE11A (0.54) | PDE11ACNR1CNR2MAT2ALMNA | |
| SCHEMBL8285283 | 0.83 | PDE11A (0.57) | PDE11ACNR1CNR2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |