Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285254 | 0.88 | PDE11A (0.59) | PDE11AKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL8285257 | 0.86 | PDE11A (0.57) | PDE11AKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL8285263 | 0.85 | PDE11A (0.56) | PDE11AKMT2AMEN1GAAMAPT | |
| SCHEMBL8286114 | 0.85 | PDE11A (0.53) | PDE11AKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL8362903 | 0.84 | PDE11A (0.56) | PDE11AKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL8285280 | 0.84 | PDE11A (0.56) | PDE11AKMT2ATDP1MEN1ALDH1A1 | |
| SCHEMBL8285258 | 0.84 | PDE11A (0.55) | PDE11AKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL8287112 | 0.83 | PDE11A (0.57) | PDE11AKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL8287467 | 0.80 | PDE11A (0.45) | PDE11AKMT2ANPC1TDP1PDE4B | |
| SCHEMBL8285287 | 0.80 | PDE11A (0.63) | PDE11AKMT2ATDP1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |