Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.59 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285257 | 0.93 | PDE11A (0.57) | PDE11ACNR1CNR2MEN1KMT2A | |
| SCHEMBL8285263 | 0.92 | PDE11A (0.56) | PDE11ACNR1CNR2MEN1KMT2A | |
| SCHEMBL8362903 | 0.91 | PDE11A (0.56) | PDE11ACNR1CNR2MEN1KMT2A | |
| SCHEMBL8285280 | 0.91 | PDE11A (0.56) | PDE11ACNR1CNR2MEN1KMT2A | |
| SCHEMBL8285258 | 0.90 | PDE11A (0.55) | PDE11ACNR1CNR2MEN1KMT2A | |
| SCHEMBL8285266 | 0.88 | PDE11A (0.57) | PDE11AMEN1KMT2AGAAMAPT | |
| SCHEMBL8285287 | 0.86 | PDE11A (0.63) | PDE11ACNR1CNR2MEN1KMT2A | |
| SCHEMBL8286114 | 0.86 | PDE11A (0.53) | PDE11AMEN1KMT2APOLBLMNA | |
| SCHEMBL8285267 | 0.85 | PDE11A (0.62) | PDE11ACNR1CNR2MEN1KMT2A | |
| SCHEMBL8287167 | 0.85 | PDE11A (0.44) | PDE11APOLBGAAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |