Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 4/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8362903 | 0.92 | PDE11A (0.56) | PDE11AMEN1KMT2AMAPTPOLB | |
| SCHEMBL8285254 | 0.92 | PDE11A (0.59) | PDE11AMEN1KMT2AMAPTPOLB | |
| SCHEMBL8285257 | 0.90 | PDE11A (0.57) | PDE11AMEN1KMT2AMAPTPOLB | |
| SCHEMBL8285280 | 0.88 | PDE11A (0.56) | PDE11AMEN1KMT2AMAPTGAA | |
| SCHEMBL8285258 | 0.88 | PDE11A (0.55) | PDE11AMEN1KMT2AMAPTPOLB | |
| SCHEMBL8286114 | 0.87 | PDE11A (0.53) | PDE11AMEN1KMT2AMAPTPOLB | |
| SCHEMBL8285152 | 0.85 | PDE11A (0.56) | PDE11AMEN1KMT2AMAPTPOLB | |
| SCHEMBL8285266 | 0.85 | PDE11A (0.57) | PDE11AMEN1KMT2AMAPTGAA | |
| SCHEMBL8285287 | 0.84 | PDE11A (0.63) | PDE11AMEN1KMT2AMAPTPOLB | |
| SCHEMBL8287836 | 0.83 | PDE11A (0.56) | PDE11AMAPTPOLBTP53RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |