Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.56 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | STAT1 | P42224 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | DDX3X | O00571 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285257 | 0.91 | PDE11A (0.57) | PDE11ACNR1CNR2MEN1KMT2A | |
| SCHEMBL8285254 | 0.91 | PDE11A (0.59) | PDE11ACNR1CNR2MEN1KMT2A | |
| SCHEMBL8362903 | 0.89 | PDE11A (0.56) | PDE11ACNR1CNR2MEN1KMT2A | |
| SCHEMBL8285258 | 0.89 | PDE11A (0.55) | PDE11ACNR1CNR2MEN1KMT2A | |
| SCHEMBL8285263 | 0.88 | PDE11A (0.56) | PDE11ACNR1CNR2MEN1KMT2A | |
| SCHEMBL8287847 | 0.86 | PDE11A (0.60) | PDE11ACNR1CNR2MEN1KMT2A | |
| SCHEMBL8285266 | 0.84 | PDE11A (0.57) | PDE11AMEN1KMT2AMAPTGAA | |
| SCHEMBL8285287 | 0.83 | PDE11A (0.63) | PDE11ACNR1CNR2MEN1KMT2A | |
| SCHEMBL8286114 | 0.82 | PDE11A (0.53) | PDE11AMEN1KMT2AMAPTTSHR | |
| SCHEMBL8287476 | 0.82 | PDE11A (0.56) | PDE11ACNR1CNR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |