Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286426 | 0.86 | PDE11A (0.39) | KDM4EHTTALDH1A1LMNANPSR1 | |
| SCHEMBL8286457 | 0.83 | LMNA (0.38) | HTTALDH1A1LMNAL3MBTL1NPSR1 | |
| SCHEMBL8286140 | 0.83 | PDE11A (0.37) | HTTALDH1A1LMNANPSR1USP2 | |
| SCHEMBL8285340 | 0.83 | PDE11A (0.45) | KDM4EALDH1A1LMNAL3MBTL1TP53 | |
| SCHEMBL8287417 | 0.83 | HTT (0.47) | KDM4EHTTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL8286424 | 0.83 | MAT2A (0.41) | KDM4EHTTALDH1A1LMNANPSR1 | |
| SCHEMBL8286076 | 0.83 | PDE11A (0.39) | KDM4EHTTALDH1A1LMNANPSR1 | |
| SCHEMBL5872270 | 0.83 | PDE11A (0.44) | KDM4EHTTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL8286083 | 0.82 | PDE11A (0.38) | KDM4EHTTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL8286078 | 0.82 | HTR6 (0.41) | HTTALDH1A1LMNANPSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |